Recettore della somatostatina 4
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| Recettore della somatostatina 4 | |
|---|---|
| Gene | |
| HUGO | SSTR4 |
| Entrez | 6754 |
| Locus | Chr. 20 p11.21 |
| Proteina | |
| OMIM | 182454 |
| UniProt | P31391 |
Il recettore della somatostatina 4 è una proteina recettoriale codificata nell'uomo dal gene SSTR4[1][2].
La somatostatina agisce in molti siti recettoriali inibendo il rilascio di ormoni e altre proteine secretorie. Gli effetti biologici sono probabilmente mediati da una famiglia di recettori accoppiati a proteine G espressi in modalità tessuto-specifiche. In particolare SSTR4 fa parte della superfamiglia dei recettori con sette domini transmembrana ed è iperespresso, nel feto e nell'adulto, a livello del cervello e del polmone[2].
Note[modifica | modifica wikitesto]
- ^ Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schule R, Cloning and characterization of a fourth human somatostatin receptor, in Proc Natl Acad Sci U S A, vol. 90, n. 9, giugno 1993, pp. 4196–200, DOI:10.1073/pnas.90.9.4196, PMC 46473, PMID 8483934.
- ^ a b Entrez Gene: SSTR4 somatostatin receptor 4, su ncbi.nlm.nih.gov.
Voci correlate[modifica | modifica wikitesto]
Approfondimenti[modifica | modifica wikitesto]
- Patel YC, Somatostatin and its receptor family, in Frontiers in neuroendocrinology, vol. 20, n. 3, 1999, pp. 157–98, DOI:10.1006/frne.1999.0183, PMID 10433861.
- Yamada Y, Post SR, Wang K, HS Tager, GI Bell e S Seino, Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney, in Proc. Natl. Acad. Sci. U.S.A., vol. 89, n. 1, 1992, pp. 251–5, DOI:10.1073/pnas.89.1.251, PMC 48214, PMID 1346068.
- Demchyshyn LL, Srikant CB, Sunahara RK, G Kent, P Seeman, HH Van Tol, R Panetta, YC Patel e HB Niznik, Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20, in Mol. Pharmacol., vol. 43, n. 6, 1993, pp. 894–901, PMID 8100352.
- Yasuda K, Espinosa R, Davis EM, Michelle M. Le Beau e Graeme I. Bell, Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2, in Genomics, vol. 17, n. 3, 1993, pp. 785–6, DOI:10.1006/geno.1993.1410, PMID 8244401.
- Yamada Y, Kagimoto S, Kubota A, K. Yasuda, K. Masuda, Y. Someya, Y. Ihara, Q. Li e H. Imura, Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype, in Biochem. Biophys. Res. Commun., vol. 195, n. 2, 1993, pp. 844–52, DOI:10.1006/bbrc.1993.2122, PMID 8373420.
- Kaupmann K, Bruns C, Hoyer D, Klaus Seuwen e Hermann Lübbert, Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain, in FEBS Lett., vol. 331, 1–2, 1993, pp. 53–9, DOI:10.1016/0014-5793(93)80296-7, PMID 8405411.
- Yamada Y, Stoffel M, Espinosa R, Kun-san Xiang, Mitsuko Seino, Susumu Seino, Michelle M. Le Beau e Graeme I. Bell, Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms, in Genomics, vol. 15, n. 2, 1993, pp. 449–52, DOI:10.1006/geno.1993.1088, PMID 8449518.
- Xu Y, Song J, Bruno JF, Berelowitz M, Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4, in Biochem. Biophys. Res. Commun., vol. 193, n. 2, 1993, pp. 648–52, DOI:10.1006/bbrc.1993.1673, PMID 8512564.
- Fukusumi S, Kitada C, Takekawa S, Hideki Kizawa, Junko Sakamoto, Masaomi Miyamoto, Shuji Hinuma, Kazuaki Kitano e Masahiko Fujino, Identification and characterization of a novel human cortistatin-like peptide, in Biochem. Biophys. Res. Commun., vol. 232, n. 1, 1997, pp. 157–63, DOI:10.1006/bbrc.1997.6252, PMID 9125122.
- de Lecea L, Ruiz-Lozano P, Danielson PE, Jessica Peelle-Kirley, Pamela E. Foye, Wayne N. Frankel e J.Gregor Sutcliffe, Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin, in Genomics, vol. 42, n. 3, 1997, pp. 499–506, DOI:10.1006/geno.1997.4763, PMID 9205124.
- Jaïs P, Terris B, Ruszniewski P, M. Leromancer, F. Reyl-Desmars, C. Vissuzaine, G. Cadiot, M. Mignon e M. J. M. Lewin, Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours, in Eur. J. Clin. Invest., vol. 27, n. 8, 1997, pp. 639–44, DOI:10.1046/j.1365-2362.1997.1740719.x, PMID 9279525.
- Sharma K, Patel YC, Srikant CB, C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest, in Mol. Endocrinol., vol. 13, n. 1, 1999, pp. 82–90, DOI:10.1210/me.13.1.82, PMID 9892014.
- Forssell-Aronsson EB, Nilsson O, Bejegård SA, L Kölby, P Bernhardt, J Mölne, SH Hashemi, B Wängberg e LE Tisell, 111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors, in J. Nucl. Med., vol. 41, n. 4, 2000, pp. 636–42, PMID 10768564.
- Zatelli MC, Tagliati F, Taylor JE, R Rossi, MD Culler e EC Degli Uberti, Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt, in J. Clin. Endocrinol. Metab., vol. 86, n. 5, 2001, pp. 2161–9, DOI:10.1210/jc.86.5.2161, PMID 11344221.
- Talme T, Ivanoff J, Hägglund M, R. J. J. Van Neerven, A. Ivanoff e K. G. Sundqvist, Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3, in Clin. Exp. Immunol., vol. 125, n. 1, 2001, pp. 71–9, DOI:10.1046/j.1365-2249.2001.01577.x, PMC 1906108, PMID 11472428.
- Pasquali D, Notaro A, Esposito D, P Vassallo, G Bonavolontà, A Bellastella e AA Sinisi, [Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy], in Minerva Endocrinol., vol. 26, n. 3, 2002, pp. 175–9, PMID 11753241.
- Deloukas P, Matthews LH, Ashurst J, J. Burton, J. G. R. Gilbert, M. Jones, G. Stavrides, J. P. Almeida e A. K. Babbage, The DNA sequence and comparative analysis of human chromosome 20, in Nature, vol. 414, n. 6866, 2002, pp. 865–71, DOI:10.1038/414865a, PMID 11780052.
- Papotti M, Bongiovanni M, Volante M, Allìa e., Landolfi s., Helboe l., Schindler m., Cole s. e Bussolati g., Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis, in Virchows Arch., vol. 440, n. 5, 2002, pp. 461–75, DOI:10.1007/s00428-002-0609-x, PMID 12021920.
Collegamenti esterni[modifica | modifica wikitesto]
- Recettore della somatostatina: sst4, su IUPHAR Database of Receptors and Ion Channels, International Union of Basic and Clinical Pharmacology.
- Mesh, su nlm.nih.gov.
