Recettore della somatostatina 2

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Recettore della somatostatina 2
Gene
HUGO SSTR2
Entrez 6752
Locus Chr. 17 q25.1
Proteina
OMIM 182452
UniProt P30874

Il recettore della somatostatina 2 è una proteina recettoriale codificata nell'uomo dal gene SSTR2[1].

La somatostatina agisce in molti siti recettoriali inibendo il rilascio di ormoni e altre proteine secretorie. Gli effetti biologici sono probabilmente mediati da una famiglia di recettori accoppiati a proteine G espressi in modalità tessuto-specifiche. In particolare SSTR4 fa parte della superfamiglia dei recettori con sette domini transmembrana ed è iperespresso a livello del cervello e del rene[2].

Interazioni[modifica | modifica sorgente]

Il recettore della somatostatina è stato dimostrato interagire con la proteina SHANK2[3].

Note[modifica | modifica sorgente]

  1. ^ Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI, Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms in Genomics, vol. 15, n. 2, aprile 1993, pp. 449–52. DOI:10.1006/geno.1993.1088, PMID 8449518.
  2. ^ Entrez Gene: SSTR2 somatostatin receptor 2.
  3. ^ H Zitzer, Hönck H H, Bächner D, Richter D, Kreienkamp H J, Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain in J. Biol. Chem., vol. 274, n. 46, UNITED STATES, novembre 1999, pp. 32997–3001. DOI:10.1074/jbc.274.46.32997, ISSN 0021-9258, PMID 10551867.

Voci correlate[modifica | modifica sorgente]

Approfondimenti[modifica | modifica sorgente]

  • Yamada Y, Post SR, Wang K, HS Tager, GI Bell e S Seino, Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney in Proc. Natl. Acad. Sci. U.S.A., vol. 89, n. 1, 1992, pp. 251–5. DOI:10.1073/pnas.89.1.251, PMC 48214, PMID 1346068.
  • Reubi JC, Waser B, Schaer JC, Markwalder R, Somatostatin receptors in human prostate and prostate cancer in J. Clin. Endocrinol. Metab., vol. 80, n. 9, 1995, pp. 2806–14. DOI:10.1210/jc.80.9.2806, PMID 7673428.
  • Kagimoto S, Yamada Y, Kubota A, Y. Someya, Y. Ihara, K. Yasuda, T. Kozasa, H. Imura e S. Seino, Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein in Biochem. Biophys. Res. Commun., vol. 202, n. 2, 1994, pp. 1188–95. DOI:10.1006/bbrc.1994.2054, PMID 7914078.
  • Fujita T, Yamaji Y, Sato M, Koji Murao e Jiro Takahara, Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines in Life Sci., vol. 55, n. 23, 1994, pp. 1797–806. DOI:10.1016/0024-3205(94)90090-6, PMID 7968260.
  • Patel YC, Greenwood M, Kent G, R. Panetta e C.B. Srikant, Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation in Biochem. Biophys. Res. Commun., vol. 192, n. 1, 1993, pp. 288–94. DOI:10.1006/bbrc.1993.1412, PMID 8386508.
  • Fukusumi S, Kitada C, Takekawa S, Hideki Kizawa, Junko Sakamoto, Masaomi Miyamoto, Shuji Hinuma, Kazuaki Kitano e Masahiko Fujino, Identification and characterization of a novel human cortistatin-like peptide in Biochem. Biophys. Res. Commun., vol. 232, n. 1, 1997, pp. 157–63. DOI:10.1006/bbrc.1997.6252, PMID 9125122.
  • Jaïs P, Terris B, Ruszniewski P, M. Leromancer, F. Reyl-Desmars, C. Vissuzaine, G. Cadiot, M. Mignon e M. J. M. Lewin, Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours in Eur. J. Clin. Invest., vol. 27, n. 8, 1997, pp. 639–44. DOI:10.1046/j.1365-2362.1997.1740719.x, PMID 9279525.
  • Lopez F, Estève JP, Buscail L, N Delesque, N Saint-Laurent, M Théveniau, C Nahmias, N Vaysse e C Susini, The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling in J. Biol. Chem., vol. 272, n. 39, 1997, pp. 24448–54. DOI:10.1074/jbc.272.39.24448, PMID 9305905.
  • Tsutsumi A, Takano H, Ichikawa K, Seiichi Kobayashi e Takao Koike, Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells in Cell. Immunol., vol. 181, n. 1, 1997, pp. 44–9. DOI:10.1006/cimm.1997.1193, PMID 9344495.
  • Sharma K, Patel YC, Srikant CB, C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest in Mol. Endocrinol., vol. 13, n. 1, 1999, pp. 82–90. DOI:10.1210/me.13.1.82, PMID 9892014.
  • Kumar U, Sasi R, Suresh S, A. Patel, M. Thangaraju, P. Metrakos, S. C. Patel e Y. C. Patel, Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis in Diabetes, vol. 48, n. 1, 1999, pp. 77–85. DOI:10.2337/diabetes.48.1.77, PMID 9892225.
  • Zitzer H, Richter D, Kreienkamp HJ, Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1 in J. Biol. Chem., vol. 274, n. 26, 1999, pp. 18153–6. DOI:10.1074/jbc.274.26.18153, PMID 10373412.
  • Zitzer H, Hönck HH, Bächner D, D Richter e HJ Kreienkamp, Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain in J. Biol. Chem., vol. 274, n. 46, 2000, pp. 32997–3001. DOI:10.1074/jbc.274.46.32997, PMID 10551867.
  • Petersenn S, Rasch AC, Presch S, Frank U Beil e Heinrich M Schulte, Genomic structure and transcriptional regulation of the human somatostatin receptor type 2 in Mol. Cell. Endocrinol., vol. 157, n. 1–2, 2000, pp. 75–85. DOI:10.1016/S0303-7207(99)00161-6, PMID 10619399.
  • Kreienkamp HJ, Zitzer H, Richter D, Identification of proteins interacting with the rat somatostatin receptor subtype 2 in J. Physiol. Paris, vol. 94, n. 3–4, 2001, pp. 193–8. DOI:10.1016/S0928-4257(00)00204-7, PMID 11087996.
  • Ho MK, Yung LY, Chan JS, Jasmine H P Chan, Cecilia S S Wong e Yung H Wong, Gα14 links a variety of Gi- and Gs-coupled receptors to the stimulation of phospholipase C in Br. J. Pharmacol., vol. 132, n. 7, 2001, pp. 1431–40. DOI:10.1038/sj.bjp.0703933, PMC 1572686, PMID 11264236.
  • Zatelli MC, Tagliati F, Taylor JE, R Rossi, MD Culler e EC Degli Uberti, Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt in J. Clin. Endocrinol. Metab., vol. 86, n. 5, 2001, pp. 2161–9. DOI:10.1210/jc.86.5.2161, PMID 11344221.
  • Talme T, Ivanoff J, Hägglund M, R. J. J. Van Neerven, A. Ivanoff e K. G. Sundqvist, Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3 in Clin. Exp. Immunol., vol. 125, n. 1, 2001, pp. 71–9. DOI:10.1046/j.1365-2249.2001.01577.x, PMC 1906108, PMID 11472428.
  • Klisovic DD, O'Dorisio MS, Katz SE, JW Sall, D Balster, TM O'Dorisio, E Craig e M Lubow, Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study in Invest. Ophthalmol. Vis. Sci., vol. 42, n. 10, 2001, pp. 2193–201. PMID 11527930.

Collegamenti esterni[modifica | modifica sorgente]