Monoossigenasi aspecifica

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monoossigenasi aspecifica
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Numero EC 1.14.14.1
Classe Ossidoreduttasi
Nome sistematico
substrato,flavoproteina ridotta:ossigeno ossidoreduttasi (RH-idrossilante o -epossidante)
Altri nomi
monoossigenasi microsomale; xenobiotico monoossigenasi; aril-4-monoossigenasi; aril idrocarburo idrossilasi; P-450 microsomiale; monoossigenasi legata a flavoproteina; flavoproteina monoossigenasi
Banche dati BRENDA, EXPASY, GTD, KEGG, PDB
Fonte: IUBMB

La monoossigenasi aspecifica è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione:

RH + flavoproteina ridotta + O2 ROH + flavoproteina ossidata + H2O

Si tratta di un gruppo di proteine eme-tiolate (P-450) che agiscono su un ampio spettro di substrati, tra cui molti xenobiotici, steroidi, acidi grassi, vitamine e prostaglandine. Le reazioni catalizzate includono idrossilazione, epossidazione, N-ossidazione, sulfoossidazione, deamminazione, N-, S- e O-dealchilazioni.

Insieme alla NADPH-emoproteina reduttasi (numero EC 1.6.2.4[1]), essa forma un sistema in cui due equivalenti di riduzione sono forniti da NADPH. Alcune delle reazioni attribuite alla alcano 1-monoossigenasi (numero EC 1.14.15.3[1] sono in realtà catalizzate dalla monoossigenasi aspecifica.

Note[modifica | modifica sorgente]

  1. ^ a b (EN) 1.6.2.4 in ExplorEnz — The Enzyme Database, IUBMB.

Bibliografia[modifica | modifica sorgente]

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