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== Classificazione ==
== Classificazione ==
* - (U-74006F) Tirilazad mesilato che possiede attività: Neuroprotettiva, antiossidante e antifiammatoria.<ref name="Lo-2013">{{Cita pubblicazione |cognome = Lo | nome = BW. | coauthors = RL. Macdonald; A. Baker; MA. Levine | titolo = Clinical outcome prediction in aneurysmal subarachnoid hemorrhage using bayesian neural networks with fuzzy logic inferences. | rivista = Comput Math Methods Med | volume = 2013 |numero = | pagine = 904860 | mese = | anno = 2013 | doi = 10.1155/2013/904860 | id = PMID 23690884 }}</ref><ref name="Sharma-2012">{{Cita pubblicazione | cognome = Sharma | nome = A. | coauthors = | titolo = Pharmacological management of acute spinal cord injury. |rivista = J Assoc Physicians India | volume = 60 Suppl | numero = | pagine = 13-8 | mese = May | anno = 2012 | doi = | id = PMID 23155791 }}</ref><ref name="Hall-2011">{{Cita pubblicazione | cognome = Hall | nome = ED. | coauthors = | titolo = Antioxidant therapies for acute spinal cord injury. | rivista = Neurotherapeutics | volume = 8 | numero = 2 | pagine = 152-67 | mese = Apr | anno = 2011 | doi = 10.1007/s13311-011-0026-4 | id = PMID 21424941 }}</ref><ref name="Ilodigwe-2013">{{Cita pubblicazione | cognome = Ilodigwe| nome = D. | coauthors = GD. Murray; NF. Kassell; J. Torner; RS. Kerr; AJ. Molyneux; RL. Macdonald | titolo = Sliding dichotomy compared with fixed dichotomization of ordinal outcome scales in subarachnoid hemorrhage trials. | rivista = J Neurosurg | volume = 118 | numero = 1 | pagine = 3-12 | mese = Jan | anno = 2013 | doi = 10.3171/2012.9.JNS111383 | id = PMID 23039145 }}</ref><ref name="Biswas-2013">{{Cita pubblicazione | cognome = Biswas | nome = S. | coauthors = JW. Hwang; PA. Kirkham; I. Rahman | titolo = Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease. | rivista = Curr Med Chem | volume = 20 | numero = 12 | pagine = 1496-530 | mese = | anno = 2013 | doi = | id = PMID 22963552 }}</ref> <ref name="StromKimmel2012">{{cite book|author1=Brian L. Strom|author2=Stephen E Kimmel|author3=Sean Hennessy|title=Pharmacoepidemiology|url=http://books.google.com/books?id=fS7ygS9dnb8C&pg=PA700|accessdate=|date=5 March 2012|publisher=John Wiley & Sons|isbn=978-0-470-65475-0|pages=700–}}</ref><ref name="Villamena2013">{{cite book|author=Frederick A. Villamena|title=Molecular Basis of Oxidative Stress: Chemistry, Mechanisms, and Disease Pathogenesis|url=http://books.google.com/books?id=fhBC9HItbKwC&pg=PA389|accessdate=|date=4 June 2013|publisher=John Wiley & Sons|isbn=978-1-118-35586-2|pages=389–}}</ref><ref name="Bederson1997">{{cite book|author=Joshua B. Bederson|title=Subarachnoid Hemorrhage: Pathophysiology and Management|url=http://books.google.com/books?id=8N1ACp5FEqQC&pg=PA143|accessdate=|year=1997|publisher=Thieme|isbn=978-1-879284-43-2|pages=143–}}</ref><ref name="Farooqui2010">{{cite book|author=Akhlaq A. Farooqui|title=Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases|url=http://books.google.com/books?id=q_G5aon0WbAC&pg=PA161|accessdate=|date=1 January 2010|publisher=Springer|isbn=978-1-4419-6652-0|pages=161–}}</ref><ref name="WilliamsLalonde2012">{{cite book|author1=J. Andrew Williams|author2=Richard Lalonde|author3=Jeffrey R. Koup|coauthors=David D. Christ|title=Predictive Approaches in Drug Discovery and Development: Biomarkers and In Vitro / In Vivo Correlations|url=http://books.google.com/books?id=ipPrgYmUukYC&pg=PA10|accessdate=|date=14 February 2012|publisher=John Wiley & Sons|isbn=978-1-118-23026-8|pages=10–}}</ref>
* - (U-74006F) Tirilazad mesilato che possiede attività: Neuroprotettiva, antiossidante e antifiammatoria.<ref name="Lo-2013">{{Cita pubblicazione |cognome = Lo | nome = BW. | coauthors = RL. Macdonald; A. Baker; MA. Levine | titolo = Clinical outcome prediction in aneurysmal subarachnoid hemorrhage using bayesian neural networks with fuzzy logic inferences. | rivista = Comput Math Methods Med | volume = 2013 |numero = | pagine = 904860 | mese = | anno = 2013 | doi = 10.1155/2013/904860 | id = PMID 23690884 }}</ref><ref name="Sharma-2012">{{Cita pubblicazione | cognome = Sharma | nome = A. | coauthors = | titolo = Pharmacological management of acute spinal cord injury. |rivista = J Assoc Physicians India | volume = 60 Suppl | numero = | pagine = 13-8 | mese = May | anno = 2012 | doi = | id = PMID 23155791 }}</ref><ref name="Hall-2011">{{Cita pubblicazione | cognome = Hall | nome = ED. | coauthors = | titolo = Antioxidant therapies for acute spinal cord injury. | rivista = Neurotherapeutics | volume = 8 | numero = 2 | pagine = 152-67 | mese = Apr | anno = 2011 | doi = 10.1007/s13311-011-0026-4 | id = PMID 21424941 }}</ref><ref name="Ilodigwe-2013">{{Cita pubblicazione | cognome = Ilodigwe| nome = D. | coauthors = GD. Murray; NF. Kassell; J. Torner; RS. Kerr; AJ. Molyneux; RL. Macdonald | titolo = Sliding dichotomy compared with fixed dichotomization of ordinal outcome scales in subarachnoid hemorrhage trials. | rivista = J Neurosurg | volume = 118 | numero = 1 | pagine = 3-12 | mese = Jan | anno = 2013 | doi = 10.3171/2012.9.JNS111383 | id = PMID 23039145 }}</ref><ref name="Biswas-2013">{{Cita pubblicazione | cognome = Biswas | nome = S. | coauthors = JW. Hwang; PA. Kirkham; I. Rahman | titolo = Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease. | rivista = Curr Med Chem | volume = 20 | numero = 12 | pagine = 1496-530 | mese = | anno = 2013 | doi = | id = PMID 22963552 }}</ref> <ref name="StromKimmel2012">{{cite book|author1=Brian L. Strom|author2=Stephen E Kimmel|author3=Sean Hennessy|title=Pharmacoepidemiology|url=http://books.google.com/books?id=fS7ygS9dnb8C&pg=PA700|accessdate=|date=5 March 2012|publisher=John Wiley & Sons|isbn=978-0-470-65475-0|pages=700–}}</ref><ref name="Villamena2013">{{cite book|author=Frederick A. Villamena|title=Molecular Basis of Oxidative Stress: Chemistry, Mechanisms, and Disease Pathogenesis|url=http://books.google.com/books?id=fhBC9HItbKwC&pg=PA389|accessdate=|date=4 June 2013|publisher=John Wiley & Sons|isbn=978-1-118-35586-2|pages=389–}}</ref><ref name="Bederson1997">{{cite book|author=Joshua B. Bederson|title=Subarachnoid Hemorrhage: Pathophysiology and Management|url=http://books.google.com/books?id=8N1ACp5FEqQC&pg=PA143|accessdate=|year=1997|publisher=Thieme|isbn=978-1-879284-43-2|pages=143–}}</ref><ref name="Farooqui2010">{{cite book|author=Akhlaq A. Farooqui|title=Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases|url=http://books.google.com/books?id=q_G5aon0WbAC&pg=PA161|accessdate=|date=1 January 2010|publisher=Springer|isbn=978-1-4419-6652-0|pages=161–}}</ref><ref name="WilliamsLalonde2012">{{cite book|author1=J. Andrew Williams|author2=Richard Lalonde|author3=Jeffrey R. Koup|coauthors=David D. Christ|title=Predictive Approaches in Drug Discovery and Development: Biomarkers and In Vitro / In Vivo Correlations|url=http://books.google.com/books?id=ipPrgYmUukYC&pg=PA10|accessdate=|date=14 February 2012|publisher=John Wiley & Sons|isbn=978-1-118-23026-8|pages=10–}}</ref>
* - (U-74389G)<ref>{{cite book|title=Sepsis: New Insights for the Healthcare Professional: 2012 Edition|url=http://books.google.com/books?id=sRx03bcCnjYC&pg=PT84|accessdate=|date=10 December 2012|publisher=ScholarlyEditions|isbn=978-1-4649-7100-6|pages=84–}}</ref><ref name="Bimpis-2013">{{Cita pubblicazione | cognome = Bimpis | nome = A. | coauthors = A. Papalois; S. Tsakiris; K. Kalafatakis; A. Zarros; V. Gkanti; N. Skandali; H. Al-Humadi; C. Kouzelis; C. Liapi | titolo = Modulation of crucial adenosinetriphosphatase activities due to U-74389G administration in a porcine model of intracerebral hemorrhage. | rivista = Metab Brain Dis | volume = | numero = | pagine = | mese = Jan | anno = 2013 | doi = 10.1007/s11011-013-9380-8 | id = PMID 23344690 }}</ref><ref name="Bimpis-2012">{{Cita pubblicazione | cognome = Bimpis | nome = A. | coauthors = A. Papalois; S. Tsakiris; A. Zarros; K. Kalafatakis; J. Botis; V. Stolakis; KM. Zissis; C. Liapi | titolo = Activation of acetylcholinesterase after U-74389G administration in a porcine model of intracerebral hemorrhage. | rivista = Metab Brain Dis | volume = 27 | numero = 2 | pagine = 221-5 | mese = Jun | anno = 2012 | doi = 10.1007/s11011-012-9301-2 | id = PMID 22476954 }}</ref><ref name="Chang-2011">{{Cita pubblicazione | cognome = Chang | nome = YT. | coauthors = SR. Wann; KH. Hsieh; YC. Liu; CH. Chang; MS. Huang; CI. Huang; HT. Chang | titolo = The effects of lazaroid U-74389G in a rat sepsis model. | rivista = Inflamm Res | volume = 60 | numero = 1 | pagine = 29-35 | mese = Jan | anno = 2011 | doi = 10.1007/s00011-010-0231-3 | id = PMID 20623363 }}</ref><ref name="Flessas-2011">{{Cita pubblicazione | cognome = Flessas | nome = II. | coauthors = AE. Papalois; K. Toutouzas; F. Zagouri; GC. Zografos | titolo = Effects of lazaroids on intestinal ischemia and reperfusion injury in experimental models. | rivista = J Surg Res | volume = 166 | numero = 2 | pagine = 265-74 | mese = Apr | anno = 2011 | doi = 10.1016/j.jss.2010.08.031 | id = PMID 21092988 }}</ref>
* - (U-74389G)<ref>{{cite book|title=Sepsis: New Insights for the Healthcare Professional: 2012 Edition|url=http://books.google.com/books?id=sRx03bcCnjYC&pg=PT84|accessdate=|date=10 December 2012|publisher=ScholarlyEditions|isbn=978-1-4649-7100-6|pages=84–}}</ref>
* - (U-74389F)<ref name="RiedererWesemann1995">{{cite book|author1=Peter Riederer|author2=W. Wesemann|title=Journal of Neural Transmission: Supplementum|url=http://books.google.com/books?id=jrtLAQAAIAAJ|accessdate=|year=1995|publisher=Springer-Verlag}}</ref><ref name="Chang-2011">{{Cita pubblicazione | cognome = Chang | nome = YT. | coauthors = SR. Wann; KH. Hsieh; YC. Liu; CH. Chang; MS. Huang; CI. Huang; HT. Chang | titolo = The effects of lazaroid U-74389G in a rat sepsis model. | rivista = Inflamm Res | volume = 60 | numero = 1 | pagine = 29-35 | mese = Jan | anno = 2011 | doi = 10.1007/s00011-010-0231-3 | id = PMID 20623363 }}</ref><ref name="Murthy-2009">{{Cita pubblicazione | cognome = Murthy | nome = SN. | coauthors = DL. Akers; IL. Chen; TA. Osgood; R. Santiago; VA. Fonseca; PJ. Kadowitz; DB. McNamara | titolo = U74389F, a 21-aminosteroid antioxidant, improves neoendothelial morphology, but not neointimal thickening after balloon catheter injury. | rivista = Can J Physiol Pharmacol | volume = 87 | numero = 12 | pagine = 1102-9 | mese = Dec | anno = 2009 | doi = 10.1139/Y09-109 | id = PMID 20029547 }}</ref><ref name="Tsaroucha-2009">{{Cita pubblicazione | cognome = Tsaroucha | nome = AK. | coauthors = A. Papalois; S. Vernadakis; S. Adamopoulos; K. Papadopoulos; M. Lambropoulou; T. Constadinidis; A. Kyriazi; N. Papadopoulos; C. Simopoulos | titolo = The effect of U-74389G on liver recovery after acute liver ischemia-reperfusion injury in a swine model. | rivista = J Surg Res | volume = 151 | numero = 1 | pagine = 10-4 | mese = Jan | anno = 2009 | doi = 10.1016/j.jss.2008.01.024 | id = PMID 18468628 }}</ref><ref name="Yousefipour-2007">{{Cita pubblicazione | cognome = Yousefipour | nome = Z. | coauthors = H. Hercule; AO. Oyekan; MA. Newaz | titolo = Antioxidant U74389G improves glycerol-induced acute renal failure without affecting PPARgamma gene. | rivista = Ren Fail | volume = 29 | numero = 7 | pagine = 903-10 | mese = | anno = 2007 | doi = 10.1080/08860220701573483 | id = PMID 17994460 }}</ref>
* - (U-74389F)<ref name="RiedererWesemann1995">{{cite book|author1=Peter Riederer|author2=W. Wesemann|title=Journal of Neural Transmission: Supplementum|url=http://books.google.com/books?id=jrtLAQAAIAAJ|accessdate=|year=1995|publisher=Springer-Verlag}}</ref>
* - (U-78517F)<ref>{{cite book|title=The American Review of Respiratory Disease|url=http://books.google.com/books?id=_DJYAAAAYAAJ|accessdate=|year=1992|publisher=American Lung Association}}</ref><ref name="Mustafa-2011">{{Cita pubblicazione | cognome = Mustafa | nome = AG. | coauthors = JA. Wang; KM. Carrico; ED. Hall | titolo = Pharmacological inhibition of lipid peroxidation attenuates calpain-mediated cytoskeletal degradation after traumatic brain injury. | rivista = J Neurochem | volume = 117 | numero = 3 | pagine = 579-88 | mese = May | anno = 2011 | doi = 10.1111/j.1471-4159.2011.07228.x | id = PMID 21361959 }}</ref><ref name="Wang-2011">{{Cita pubblicazione | cognome = Wang | nome = H. | coauthors = Z. Zheng; Y. Gong; B. Zhu; X. Xu | titolo = U83836E inhibits retinal neurodegeneration in early-stage streptozotocin-induced diabetic rats. | rivista = Ophthalmic Res | volume = 46 | numero = 1 | pagine = 19-24 | mese = | anno = 2011 | doi = 10.1159/000321952 | id = PMID 21109760 }}</ref><ref name="Sayyed-2006">{{Cita pubblicazione | cognome = Sayyed | nome = SG. | coauthors = A. Kumar; SS. Sharma | titolo = Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy. | rivista = Life Sci | volume = 79 | numero = 8 | pagine = 777-83 | mese = Jul | anno = 2006 | doi = 10.1016/j.lfs.2006.02.033 | id = PMID 16581090 }}</ref><ref name="Labruto-2006">{{Cita pubblicazione | cognome = Labruto | nome = F. | coauthors = X. Song; G. Valen; J. Vaage | titolo = Lazaroid U-83836E improves tolerance to hemorrhagic shock and limb ischemia and reperfusion in rats and increases cardiac heat shock protein 72. | rivista = Acad Emerg Med | volume = 13 | numero = 1 | pagine = 7-12 | mese = Jan | anno = 2006 | doi = 10.1197/j.aem.2005.07.021 | id = PMID 16365323 }}</ref>
* - (U-78517F)<ref>{{cite book|title=The American Review of Respiratory Disease|url=http://books.google.com/books?id=_DJYAAAAYAAJ|accessdate=|year=1992|publisher=American Lung Association}}</ref>
* - (U-74500A)<ref name="Villamena2013">{{cite book|author=Frederick A. Villamena|title=Molecular Basis of Oxidative Stress: Chemistry, Mechanisms, and Disease Pathogenesis|url=http://books.google.com/books?id=fhBC9HItbKwC&pg=PA389|accessdate=|date=4 June 2013|publisher=John Wiley & Sons|isbn=978-1-118-35586-2|pages=389–}}</ref><ref name="Patel2007">{{cite book|author=Jigisha Patel|title=Age-related Changes in TNF Receptors and Transcription Factor Translocation in Response to TNFalpha and Abeta|url=http://books.google.com/books?id=8JZcKIKzMpQC&pg=PA12|accessdate=|year=2007|publisher=ProQuest|isbn=978-0-549-39121-0|pages=12–}}</ref>
* - (U-74500A)<ref name="Villamena2013">{{cite book|author=Frederick A. Villamena|title=Molecular Basis of Oxidative Stress: Chemistry, Mechanisms, and Disease Pathogenesis|url=http://books.google.com/books?id=fhBC9HItbKwC&pg=PA389|accessdate=|date=4 June 2013|publisher=John Wiley & Sons|isbn=978-1-118-35586-2|pages=389–}}</ref><ref name="Patel2007">{{cite book|author=Jigisha Patel|title=Age-related Changes in TNF Receptors and Transcription Factor Translocation in Response to TNFalpha and Abeta|url=http://books.google.com/books?id=8JZcKIKzMpQC&pg=PA12|accessdate=|year=2007|publisher=ProQuest|isbn=978-0-549-39121-0|pages=12–}}</ref><ref name="Bishnoi-2007">{{Cita pubblicazione | cognome = Bishnoi | nome = M. | coauthors = K. Chopra; SK. Kulkarni | titolo = U-74500A (lazaroid), a 21-aminosteroid attenuates neuroleptic-induced orofacial dyskinesia. | rivista = Methods Find Exp Clin Pharmacol | volume = 29 | numero = 9 | pagine = 601-5 | mese = Nov | anno = 2007 | doi = 10.1358/mf.2007.29.9.1161006 | id = PMID 18193111 }}</ref><ref name="Bishnoi-2012">{{Cita pubblicazione | cognome = Bishnoi | nome = M. | coauthors = RK. Boparai | titolo = An animal model to study the molecular basis of tardive dyskinesia. | rivista = Methods Mol Biol | volume = 829 | numero = | pagine = 193-201 | mese = | anno = 2012 | doi = 10.1007/978-1-61779-458-2_12 | id = PMID 22231815 }}</ref><ref name="Kaur-2003">{{Cita pubblicazione | cognome = Kaur | nome = H. | coauthors = PS. Satyanarayana; K. Chopra | titolo = Effect of U-74500A, a 21-aminosteroid on renal ischemia-reperfusion injury in rats. | rivista = Ren Fail | volume = 25 | numero = 2 | pagine = 157-71 | mese = Mar | anno = 2003 | doi = | id = PMID 12739823 }}</ref><ref name="Regan-2003">{{Cita pubblicazione | cognome = Regan | nome = RF. | coauthors = B. Rogers | titolo = Delayed treatment of hemoglobin neurotoxicity. | rivista = J Neurotrauma | volume = 20 | numero = 1 | pagine = 111-20 | mese = Jan | anno = 2003 | doi = 10.1089/08977150360517236 | id = PMID 12614593 }}</ref>
* - (U-83836E)<ref name="MorganMarshall1999">{{cite book|author1=Douglas W. Morgan|author2=Lisa A. Marshall|title=In Vivo Models of Inflammation|url=http://books.google.com/books?id=Y_Kkw6ArowEC&pg=PA124|accessdate= |date=1 January 1999|publisher=Springer|isbn=978-3-7643-5876-1|pages=124–}}</ref><ref name="Mustafa-2011">{{Cita pubblicazione | cognome = Mustafa | nome = AG. | coauthors = JA. Wang; KM. Carrico; ED. Hall | titolo = Pharmacological inhibition of lipid peroxidation attenuates calpain-mediated cytoskeletal degradation after traumatic brain injury. | rivista = J Neurochem | volume = 117 | numero = 3 | pagine = 579-88 | mese = May | anno = 2011 | doi = 10.1111/j.1471-4159.2011.07228.x | id = PMID 21361959 }}</ref><ref name="Mustafa-2010">{{Cita pubblicazione | cognome = Mustafa | nome = AG. | coauthors = IN. Singh; J. Wang; KM. Carrico; ED. Hall | titolo = Mitochondrial protection after traumatic brain injury by scavenging lipid peroxyl radicals. | rivista = J Neurochem | volume = 114 | numero = 1 | pagine = 271-80 | mese = Jul | anno = 2010 | doi = 10.1111/j.1471-4159.2010.06749.x | id = PMID 20403083 }}</ref><ref name="Xing-2009">{{Cita pubblicazione | cognome = Xing | nome = C. | coauthors = S. Lee; WJ. Kim; G. Jin; YG. Yang; X. Ji; X. Wang; EH. Lo | titolo = Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. | rivista = J Neurochem | volume = 108 | numero = 2 | pagine = 430-6 | mese = Jan | anno = 2009 | doi = 10.1111/j.1471-4159.2008.05777.x | id = PMID 19012741 }}</ref><ref name="Wang-2011">{{Cita pubblicazione | cognome = Wang | nome = H. | coauthors = Z. Zheng; Y. Gong; B. Zhu; X. Xu | titolo = U83836E inhibits retinal neurodegeneration in early-stage streptozotocin-induced diabetic rats. | rivista = Ophthalmic Res | volume = 46 | numero = 1 | pagine = 19-24 | mese = | anno = 2011 | doi = 10.1159/000321952 | id = PMID 21109760 }}</ref>
* - (U-83836E)<ref name="MorganMarshall1999">{{cite book|author1=Douglas W. Morgan|author2=Lisa A. Marshall|title=In Vivo Models of Inflammation|url=http://books.google.com/books?id=Y_Kkw6ArowEC&pg=PA124|accessdate= |date=1 January 1999|publisher=Springer|isbn=978-3-7643-5876-1|pages=124–}}</ref>
* - (PNU-101033E)<ref name="Farooqui2010">{{cite book|author=Akhlaq A. Farooqui|title=Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases|url=http://books.google.com/books?id=q_G5aon0WbAC&pg=PA161|accessdate=|date=1 January 2010|publisher=Springer|isbn=978-1-4419-6652-0|pages=161–}}</ref><ref name="Clements-2003">{{Cita pubblicazione | cognome = Clements | nome = MK. | coauthors = DW. Siemsen; SD. Swain; AJ. Hanson; LK. Nelson-Overton; TT. Rohn; MT. Quinn | titolo = Inhibition of actin polymerization by peroxynitrite modulates neutrophil functional responses. | rivista = J Leukoc Biol | volume = 73 | numero = 3 | pagine = 344-55 | mese = Mar | anno = 2003 | doi = | id = PMID 12629148 }}</ref><ref name="Row-2003">{{Cita pubblicazione | cognome = Row | nome = BW. | coauthors = R. Liu; W. Xu; L. Kheirandish; D. Gozal | titolo = Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat. | rivista = Am J Respir Crit Care Med | volume = 167 | numero = 11 | pagine = 1548-53 | mese = Jun | anno = 2003 | doi = 10.1164/rccm.200209-1050OC | id = PMID 12615622 }}</ref><ref name="Schmid-2001">{{Cita pubblicazione | cognome = Schmid | nome = D. | coauthors = GR. Burmester; R. Tripmacher; G. Fici; P. von Voigtlander; F. Buttgereit | titolo = Short-term effects of the 21-aminosteroid lazaroid tirilazad mesylate (PNU-74006F) and the pyrrolopyrimidine lazaroid PNU-101033E on energy metabolism of human peripheral blood mononuclear cells. | rivista = Biosci Rep | volume = 21 | numero = 1 | pagine = 101-10 | mese = Feb | anno = 2001 | doi = | id = PMID 11508689 }}</ref><ref name="Kuhn-1999">{{Cita pubblicazione | cognome = Kuhn | nome = DM. | coauthors = CW. Aretha; TJ. Geddes | titolo = Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration. | rivista = J Neurosci | volume = 19 | numero = 23 | pagine = 10289-94 | mese = Dec | anno = 1999 | doi = | id = PMID 10575026 }}</ref>
* - (PNU-101033E)<ref name="Farooqui2010">{{cite book|author=Akhlaq A. Farooqui|title=Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases|url=http://books.google.com/books?id=q_G5aon0WbAC&pg=PA161|accessdate=|date=1 January 2010|publisher=Springer|isbn=978-1-4419-6652-0|pages=161–}}</ref>


== Note ==
== Note ==

Versione delle 20:00, 26 giu 2013

Abbozzo
Questa voce sull'argomento farmaci è solo un abbozzo.
Contribuisci a migliorarla secondo le convenzioni di Wikipedia.

Il lazaroide o lazaroidi (famiglia chimica) è un C21-ammino-steroide, privo di attività sul metabolismo dei carboidrati (attività glucoattiva) e mineralcorticoide. Ha un potente effetto sulla lipoperossidazione, effetto simil-steroideo senza avere gli effetti collaterali tipici dello steroide ad alte dosi (Metilprednisolone). Il lazaroide agisce da “scavenger” dei radicali liberi dell'ossigeno (ROS) quali: l'anione superossido, il radicale idrossilico e i perossidi lipidici; agisce inibendo pure la lipossigenasi e la produzione e il rilascio dell'acido arachidonico.

Questa classe di farmaci prende il nome dalla parabola di Lazzaro; sono molecole studiate e brevettate, negli anni 90, dalla ricerca della Upjohn Company di Kalamazoo negli USA.

L'unica molecola, di questa classe chimica, ad aver trovato utilizzi e impieghi clinici sull'uomo nello stroke è il tirilazard mesilato.[1]

Classificazione

Note

  1. ^ HB. van der Worp, The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke., in Neurology, vol. 58, n. 1, Jan 2002, pp. 133-5, PMID 11781420.
  2. ^ BW. Lo, Clinical outcome prediction in aneurysmal subarachnoid hemorrhage using bayesian neural networks with fuzzy logic inferences., in Comput Math Methods Med, vol. 2013, 2013, p. 904860, DOI:10.1155/2013/904860, PMID 23690884.
  3. ^ A. Sharma, Pharmacological management of acute spinal cord injury., in J Assoc Physicians India, 60 Suppl, May 2012, pp. 13-8, PMID 23155791.
  4. ^ ED. Hall, Antioxidant therapies for acute spinal cord injury., in Neurotherapeutics, vol. 8, n. 2, Apr 2011, pp. 152-67, DOI:10.1007/s13311-011-0026-4, PMID 21424941.
  5. ^ D. Ilodigwe, Sliding dichotomy compared with fixed dichotomization of ordinal outcome scales in subarachnoid hemorrhage trials., in J Neurosurg, vol. 118, n. 1, Jan 2013, pp. 3-12, DOI:10.3171/2012.9.JNS111383, PMID 23039145.
  6. ^ S. Biswas, Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease., in Curr Med Chem, vol. 20, n. 12, 2013, pp. 1496-530, PMID 22963552.
  7. ^ Pharmacoepidemiology, John Wiley & Sons, 5 March 2012, pp. 700–, ISBN 978-0-470-65475-0.
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