Monoossigenasi aspecifica
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| monoossigenasi aspecifica | |
|---|---|
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| Numero EC | 1.14.14.1 |
| Classe | Ossidoreduttasi |
| Nome sistematico | |
| substrato,flavoproteina ridotta:ossigeno ossidoreduttasi (RH-idrossilante o -epossidante) | |
| Altri nomi | |
| monoossigenasi microsomale; xenobiotico monoossigenasi; aril-4-monoossigenasi; aril idrocarburo idrossilasi; P-450 microsomiale; monoossigenasi legata a flavoproteina; flavoproteina monoossigenasi | |
| Banche dati | BRENDA, EXPASY, GTD, PDB (RCSB PDB PDBe PDBj PDBsum) |
| Fonte: IUBMB | |
La monoossigenasi aspecifica è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione:
Si tratta di un gruppo di proteine eme-tiolate (P-450) che agiscono su un ampio spettro di substrati, tra cui molti xenobiotici, steroidi, acidi grassi, vitamine e prostaglandine. Le reazioni catalizzate includono idrossilazione, epossidazione, N-ossidazione, sulfoossidazione, deamminazione, N-, S- e O-dealchilazioni.
Insieme alla NADPH-emoproteina reduttasi (numero EC 1.6.2.4[1]), essa forma un sistema in cui due equivalenti di riduzione sono forniti da NADPH. Alcune delle reazioni attribuite alla alcano 1-monoossigenasi (numero EC 1.14.15.3[2] sono in realtà catalizzate dalla monoossigenasi aspecifica.
Note[modifica | modifica wikitesto]
Bibliografia[modifica | modifica wikitesto]
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