TNFRSF10A
(Reindirizzamento da DR4)
| Recettore del fattore di necrosi tissutale 10A | |
|---|---|
| Gene | |
| HUGO | TNFRSF10A APO2; CD261; DR4; TRAILR-1; TRAILR1 |
| Entrez | 8797 |
| Locus | Chr. 8 p21.3 |
| Proteina | |
| OMIM | 603611 |
| UniProt | O00220 |
Il recettore del fattore di necrosi tumorale 10A, noto anche come DR4 (death receptor 6) e TRAIL-R1 (recettore di TRAIL di tipo I) è una proteina recettoriale che, nell'essere umano, è codificata dal gene TNFRSF10A e fa parte della superfamiglia dei recettori del fattore di necrosi tumorale[1][2].
Funzione[modifica | modifica wikitesto]
Tale recettore è attivato dal legame con TRAIL, che trasduce il segnale di induzione della morte cellulare programmata, tuttavia studi condotti su ratti privi del gene che codifica per FADD hanno dimostrato che quest'ultimo è strettamente necessario per l'attività di tale sistema di trasduzione del segnale apoptotico[3]. Questo recettore può inoltre legare DAP3[4].
Note[modifica | modifica wikitesto]
- ^ Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT, TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL, in EMBO J, vol. 16, n. 17, dicembre 1997, pp. 5386–97, DOI:10.1093/emboj/16.17.5386, PMC 1170170, PMID 9311998.
- ^ Pan G, O'Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM, The receptor for the cytotoxic ligand TRAIL, in Science, vol. 276, n. 5309, aprile 1997, pp. 111–3, DOI:10.1126/science.276.5309.111, PMID 9082980.
- ^ Entrez Gene: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a, su ncbi.nlm.nih.gov.
- ^ T Miyazaki, Reed J C, A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins, in Nat. Immunol., vol. 2, n. 6, United States, giugno 2001, pp. 493–500, DOI:10.1038/88684, ISSN 1529-2908, PMID 11376335.
Bibliografia[modifica | modifica wikitesto]
- Kimberley FC, Screaton GR, Following a TRAIL: update on a ligand and its five receptors., in Cell Res., vol. 14, n. 5, 2005, pp. 359–72, DOI:10.1038/sj.cr.7290236, PMID 15538968.
- Fleury S, Thibodeau J, Croteau G, et al., HLA-DR polymorphism affects the interaction with CD4., in J. Exp. Med., vol. 182, n. 3, 1995, pp. 733–41, DOI:10.1084/jem.182.3.733, PMC 2192178, PMID 7650480.
- MacFarlane M, Ahmad M, Srinivasula SM, et al., Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL., in J. Biol. Chem., vol. 272, n. 41, 1997, pp. 25417–20, DOI:10.1074/jbc.272.41.25417, PMID 9325248.
- Schneider P, Bodmer JL, Thome M, et al., Characterization of two receptors for TRAIL., in FEBS Lett., vol. 416, n. 3, 1997, pp. 329–34, DOI:10.1016/S0014-5793(97)01231-3, PMID 9373179.
- Marsters SA, Sheridan JP, Pitti RM, et al., A novel receptor for Apo2L/TRAIL contains a truncated death domain., in Curr. Biol., vol. 7, n. 12, 1998, pp. 1003–6, DOI:10.1016/S0960-9822(06)00422-2, PMID 9382840.
- Chaudhary PM, Eby M, Jasmin A, et al., Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway., in Immunity, vol. 7, n. 6, 1998, pp. 821–30, DOI:10.1016/S1074-7613(00)80400-8, PMID 9430227.
- Schneider P, Thome M, Burns K, et al., TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB., in Immunity, vol. 7, n. 6, 1998, pp. 831–6, DOI:10.1016/S1074-7613(00)80401-X, PMID 9430228.
- Diab BY, Lambert NC, L'Faqihi FE, et al., Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis., in Immunogenetics, vol. 49, n. 1, 1999, pp. 36–44, DOI:10.1007/s002510050461, PMID 9811967.
- Costanzo A, Guiet C, Vito P, c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB., in J. Biol. Chem., vol. 274, n. 29, 1999, pp. 20127–32, DOI:10.1074/jbc.274.29.20127, PMID 10400625.
- Hymowitz SG, Christinger HW, Fuh G, et al., Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5., in Mol. Cell, vol. 4, n. 4, 1999, pp. 563–71, DOI:10.1016/S1097-2765(00)80207-5, PMID 10549288.
- Gibson SB, Oyer R, Spalding AC, et al., Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL., in Mol. Cell. Biol., vol. 20, n. 1, 2000, pp. 205–12, DOI:10.1128/MCB.20.1.205-212.2000, PMC 85076, PMID 10594023.
- Kuang AA, Diehl GE, Zhang J, Winoto A, FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts., in J. Biol. Chem., vol. 275, n. 33, 2000, pp. 25065–8, DOI:10.1074/jbc.C000284200, PMID 10862756.
- Miyazaki T, Reed JC, A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins., in Nat. Immunol., vol. 2, n. 6, 2001, pp. 493–500, DOI:10.1038/88684, PMID 11376335.
- Trauzold A, Wermann H, Arlt A, et al., CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells., in Oncogene, vol. 20, n. 31, 2001, pp. 4258–69, DOI:10.1038/sj.onc.1204559, PMID 11464292.
- Dörr J, Bechmann I, Waiczies S, et al., Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain., in J. Neurosci., vol. 22, n. 4, 2002, pp. RC209, PMID 11844843.
- Koyama S, Koike N, Adachi S, Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor., in J. Cancer Res. Clin. Oncol., vol. 128, n. 2, 2002, pp. 73–9, DOI:10.1007/s004320100292, PMID 11862476.
- Guan B, Yue P, Lotan R, Sun SY, Evidence that the human death receptor 4 is regulated by activator protein 1., in Oncogene, vol. 21, n. 20, 2002, pp. 3121–9, DOI:10.1038/sj.onc.1205430, PMID 12082627.
- Söderström TS, Poukkula M, Holmström TH, et al., Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8., in J. Immunol., vol. 169, n. 6, 2002, pp. 2851–60, PMID 12218097.
