Endotelina 2

Endotelina 2
Gene
HUGO	EDN2
Entrez	1907
Locus	Chr. 1 p34
Proteina
OMIM	131241
UniProt	P20800

Endotelina 2, anche nota come EDN2, è sia il nome di un gene umano sia il corrispondente peptide, e costituisce una delle tre isoforme delle endoteline umane.

Funzione

L'endotelina 2 appartiene alla famiglia delle endoteline, dei peptidi ad azione vasocostrittrice. La preproteina è processata ad una forma matura corta che funziona come ligando per i recettori delle endoteline che trasducono il segnale all'interno delle cellule bersaglio. Questo gene è coinvolto in diversi processi biologici, come l'ipertensione e l'ovulazione.

Letture ulteriori

• Arjomand-Nahad, F., O. Landt; K. Stangl; K. Diefenbach; I. Roots (2006). Fifteen polymorphisms in endothelin-1, endothelin-2 and endothelin-receptor-A genotyped by four duplex assays and seven simple assays on a LightCycler using hybridization probes.. Clin Chem Lab Med 44 (8): 929-32. DOI:10.1515/CCLM.2006.180. PMID 16879056.
• Ryckman, KK., NH. Morken; MJ. White; DR. Velez; R. Menon; SJ. Fortunato; P. Magnus; SM. Williams; B. Jacobsson (2010). Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.. PLoS One 5 (2): e9040. DOI:10.1371/journal.pone.0009040. PMID 20140262.
• Dimoulios, P., G. Kolios; G. Notas; E. Matrella; C. Xidakis; M. Koulentaki; N. Tsagarakis; A. Kouroumalis; E. Kouroumalis (Feb 2005). Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis.. Aliment Pharmacol Ther 21 (3): 227-34. DOI:10.1111/j.1365-2036.2005.02307.x. PMID 15691296.
• Menon, R., B. Pearce; DR. Velez; M. Merialdi; SM. Williams; SJ. Fortunato; P. Thorsen (2009). Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.. Reprod Biol Endocrinol 7: 62. DOI:10.1186/1477-7827-7-62. PMID 19527514.
• Kotake-Nara, E., K. Saida (2006). Endothelin-2/vasoactive intestinal contractor: regulation of expression via reactive oxygen species induced by CoCl2, and Biological activities including neurite outgrowth in PC12 cells.. ScientificWorldJournal 6: 176-86. DOI:10.1100/tsw.2006.37. PMID 16493522.
• Paulino, EC., AA. Steil; S. Jancar (Jul 2006). Effect of endothelins on human neutrophil activation by immune complexes.. Int Immunopharmacol 6 (7): 1119-25. DOI:10.1016/j.intimp.2006.01.022. PMID 16714215.
• Arjomand-Nahad, F., O. Landt; K. Stangl; K. Diefenbach; I. Roots (2006). Fifteen polymorphisms in endothelin-1, endothelin-2 and endothelin-receptor-A genotyped by four duplex assays and seven simple assays on a LightCycler using hybridization probes.. Clin Chem Lab Med 44 (8): 929-32. DOI:10.1515/CCLM.2006.180. PMID 16879056.
• Ryckman, KK., NH. Morken; MJ. White; DR. Velez; R. Menon; SJ. Fortunato; P. Magnus; SM. Williams; B. Jacobsson (2010). Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.. PLoS One 5 (2): e9040. DOI:10.1371/journal.pone.0009040. PMID 20140262.
• Dimoulios, P., G. Kolios; G. Notas; E. Matrella; C. Xidakis; M. Koulentaki; N. Tsagarakis; A. Kouroumalis; E. Kouroumalis (Feb 2005). Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis.. Aliment Pharmacol Ther 21 (3): 227-34. DOI:10.1111/j.1365-2036.2005.02307.x. PMID 15691296.
• Menon, R., B. Pearce; DR. Velez; M. Merialdi; SM. Williams; SJ. Fortunato; P. Thorsen (2009). Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.. Reprod Biol Endocrinol 7: 62. DOI:10.1186/1477-7827-7-62. PMID 19527514.
• Kotake-Nara, E., K. Saida (2006). Endothelin-2/vasoactive intestinal contractor: regulation of expression via reactive oxygen species induced by CoCl2, and Biological activities including neurite outgrowth in PC12 cells.. ScientificWorldJournal 6: 176-86. DOI:10.1100/tsw.2006.37. PMID 16493522.
• Paulino, EC., AA. Steil; S. Jancar (Jul 2006). Effect of endothelins on human neutrophil activation by immune complexes.. Int Immunopharmacol 6 (7): 1119-25. DOI:10.1016/j.intimp.2006.01.022. PMID 16714215.
• Arjomand-Nahad, F., O. Landt; K. Stangl; K. Diefenbach; I. Roots (2006). Fifteen polymorphisms in endothelin-1, endothelin-2 and endothelin-receptor-A genotyped by four duplex assays and seven simple assays on a LightCycler using hybridization probes.. Clin Chem Lab Med 44 (8): 929-32. DOI:10.1515/CCLM.2006.180. PMID 16879056.
• Ryckman, KK., NH. Morken; MJ. White; DR. Velez; R. Menon; SJ. Fortunato; P. Magnus; SM. Williams; B. Jacobsson (2010). Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.. PLoS One 5 (2): e9040. DOI:10.1371/journal.pone.0009040. PMID 20140262.
• Dimoulios, P., G. Kolios; G. Notas; E. Matrella; C. Xidakis; M. Koulentaki; N. Tsagarakis; A. Kouroumalis; E. Kouroumalis (Feb 2005). Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis.. Aliment Pharmacol Ther 21 (3): 227-34. DOI:10.1111/j.1365-2036.2005.02307.x. PMID 15691296.
• Menon, R., B. Pearce; DR. Velez; M. Merialdi; SM. Williams; SJ. Fortunato; P. Thorsen (2009). Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.. Reprod Biol Endocrinol 7: 62. DOI:10.1186/1477-7827-7-62. PMID 19527514.
• Kotake-Nara, E., K. Saida (2006). Endothelin-2/vasoactive intestinal contractor: regulation of expression via reactive oxygen species induced by CoCl2, and Biological activities including neurite outgrowth in PC12 cells.. ScientificWorldJournal 6: 176-86. DOI:10.1100/tsw.2006.37. PMID 16493522.
• Paulino, EC., AA. Steil; S. Jancar (Jul 2006). Effect of endothelins on human neutrophil activation by immune complexes.. Int Immunopharmacol 6 (7): 1119-25. DOI:10.1016/j.intimp.2006.01.022. PMID 16714215.
• Darrah, R., E. McKone; C. O'Connor; C. Rodgers; A. Genatossio; S. McNamara; R. Gibson; J. Stuart Elborn; M. Ennis; CG. Gallagher; N. Kalsheker (Mar 2010). EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity.. Physiol Genomics 41 (1): 71-7. DOI:10.1152/physiolgenomics.00185.2009. PMID 20028935.
• Bailey, SD., C. Xie; R. Do; A. Montpetit; R. Diaz; V. Mohan; B. Keavney; S. Yusuf; HC. Gerstein; JC. Engert; S. Anand (Oct 2010). Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.. Diabetes Care 33 (10): 2250-3. DOI:10.2337/dc10-0452. PMID 20628086.

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