Parametasone

Isoflupredone
Nome IUPAC
(6α,11β,16α)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Nomi alternativi
(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Caratteristiche generali
Formula bruta o molecolare	C22H29FO5
Massa molecolare (u)	392,467 g/mol-1
Numero CAS	53-33-8
Numero EINECS	200-169-2
PubChem	5875
DrugBank	DBDB01384
SMILES	CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)CO)O)C)O)C)F
Indicazioni di sicurezza

Il Parametasone è un glucocorticoide fluorinato-alogenato dalle proprietà antiinfiammatorie e immunodepressive.

Bibliografia

• Wershil BK, Furuta GT, Lavigne JA, Choudhury AR, Wang ZS, Galli SJ, Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms, in International Archives of Allergy and Immunology, vol. 107, 1–3, 1995, pp. 323–4, DOI:10.1159/000237015, PMID 7613160.
• Riccardi C, Cifone MG, Migliorati G, Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes, in Cell Death and Differentiation, vol. 6, n. 12, dicembre 1999, pp. 1182–9, DOI:10.1038/sj.cdd.4400609, PMID 10637434.
• Lavista Llanos S, Roldán A, Effect of dexamethasone on nitric oxide (NO.) production by cultured astrocytes, in Biocell, vol. 23, n. 1, aprile 1999, pp. 29–35, PMID 10904533.