Mdm2

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Struttura tridimensionale della Mdm2

Mdm2 è il nome sia del gene che della corrispettiva proteina che svolge la funzione di principale inibitore di p53, andandosi a legare ad esso ed inducendone l'ubiquitinazione e quindi la degradazione tramite proteosoma. Mdm2 appartiene pertanto alla famiglia delle ligasi E3.[1][2]

Interazioni[modifica | modifica wikitesto]

Mdm2 è regolata da molte proteine e miRNA per il suo ruolo centrale nel regolare p53. Interagisce con p53 inducendone la degradazione. Ciononostante p53 incrementa l'attività e la produzione di Mdm2 sia direttamente che indirettamente, formando così un feedback negativo autoregolatorio. La proteina ARF (conosciuta anche come p14) è un inibitore di Mdm2.

Mdm2 interagisce con le seguenti proteine:

Interazioni farmacologiche[modifica | modifica wikitesto]

La molecola nutlina inibisce l'interazione tra Mdm2 e p53 incrementanto la stabilità di quest'ultimo, ciononostante è ancora in fase di sperimentazione.[50]


Voci correlate[modifica | modifica wikitesto]

Note[modifica | modifica wikitesto]

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