File:The effect of an aging TME on tumor progression.jpg
The_effect_of_an_aging_TME_on_tumor_progression.jpg (708 × 544 pixel, dimensione del file: 112 KB, tipo MIME: image/jpeg)
 |
Questo file e la sua pagina di descrizione (discussione · modifica) si trovano su Wikimedia Commons (?) |
Dettagli
| Descrizione |
Italiano: The effect of an aging TME on tumor progression. Age-induced changes in the structure and function of the ECM promote the occurrence and development of tumors. The integrity of the ECM is greatly reduced with age, which can promote the development of cancer. In the aging TME, stromal cells are disordered and loosely arranged, which may also lead to tumor progression and metastasis. Moreover, age-induced secretion of SASP, such as the accumulation of several factors, including IL-6, IL-8, and IL-10, is a key factor in inducing tumorigenesis and progression. The aging TME also exhibits an infiltration of immunosuppressive cells, such as MDSCs and Tregs. The increase in immunosuppressive M2 macrophages and N2 neutrophils may further promote immunosuppression, while immunosenescence of effector T cells, NK cells, macrophages, and DCs significantly reduces their cytotoxic activity, leading to tumor escape and tumor progression |
| Data | |
| Fonte | Lian, Jingyao (2020-11-10). "Immunosenescence: a key player in cancer development". Journal of hematology & oncology 13 (1). Springer Science and Business Media LLC. DOI:10.1186/s13045-020-00986-z. PMID 33168037. PMC: 7653700. ISSN 1756-8722. |
| Autore |
Jingyao Lian 1 2, Ying Yue 1 2 3, Weina Yu 1 2, Yi Zhang 4 5 1-Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China. 2-State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, 450052, Henan, China. 3-Clinical Laboratory, Henan Medical College Hospital Workers, Zhengzhou, 450000, Henan, China. 4-Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China. yizhang@zzu.edu.cn. 5-State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, 450052, Henan, China. yizhang@zzu.edu.cn. |
Licenza
- Tu sei libero:
- di condividere – di copiare, distribuire e trasmettere quest'opera
- di modificare – di adattare l'opera
- Alle seguenti condizioni:
- attribuzione – Devi fornire i crediti appropriati, un collegamento alla licenza e indicare se sono state apportate modifiche. Puoi farlo in qualsiasi modo ragionevole, ma non in alcun modo che suggerisca che il licenziante approvi te o il tuo uso.
- condividi allo stesso modo – Se remixi, trasformi o sviluppi il materiale, devi distribuire i tuoi contributi in base alla stessa licenza o compatibile all'originale.
Cronologia del file
Fare clic su un gruppo data/ora per vedere il file come si presentava nel momento indicato.
| Data/Ora | Miniatura | Dimensioni | Utente | Commento | |
|---|---|---|---|---|---|
| attuale | 16:54, 14 giu 2021 | | 708 × 544 (112 KB) | OppidumNissenae | Uploaded a work by Jingyao Lian 1 2, Ying Yue 1 2 3, Weina Yu 1 2, Yi Zhang 4 5 1-Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China. 2-State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou, 450052, Henan, China. 3-Clinical Laboratory, Henan Medical College Hospital Workers, Zhengzhou, 450000, Henan, China. 4-Biotherapy Center and Cancer Center, The First Affiliated Hospital... |
Pagine che usano questo file
La seguente pagina usa questo file:
