Italiano: Genetic regulatory mechanisms affected by immunosenescence. Regulation of cellular function is often mediated by changes at the genetic level. Covalent modifications on histone tails modulate the accessibility of DNA for transcription, methylation of CpG sequences in promoter regions can affect transcription factor binding, and miRNA expression can modulate gene silencing through a number of different mechanisms at the post-transcriptional level. All of these have been shown to be differentially regulated to some capacity with aging and associated with changes in immune cell function.