Corismato sintasi

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Modello tridimensionale dell'enzima
Modello tridimensionale dell'enzima
Numero EC 4.2.3.5
Classe Liasi
Banche dati BRENDA, EXPASY, GTD, KEGG, PDB
Fonte: IUBMB

La corismato sintasi è un enzima numero EC 4.2.3.5[1] appartenente alla classe delle liasi, che catalizza la seguente reazione:

5-O-(1-carbossivinil)-3-fosfoshikimato \rightleftharpoons corismato + fosfato

Note[modifica | modifica wikitesto]

  1. ^ (EN) 4.2.3.5 in ExplorEnz — The Enzyme Database, IUBMB.

Bibliografia[modifica | modifica wikitesto]

  • (EN) Gaertner FH, Cole KW, Properties of chorismate synthase in Neurospora crassa in J. Biol. Chem., vol. 248, nº 13, 1973, pp. 4602–9, PMID 4146266.
  • (EN) Morell H, Clark MJ, Knowles PF, Sprinson DB, The enzymic synthesis of chorismic and prephenic acids from 3-enolpyruvylshikimic acid 5-phosphate in J. Biol. Chem., vol. 242, nº 1, 1967, pp. 82–90, PMID 4289188.
  • (EN) Welch GR, Cole KW, Gaertner FH, Chorismate synthase of Neurospora crassa: a flavoprotein in Arch. Biochem. Biophys., vol. 165, nº 2, 1974, pp. 505–18, DOI:10.1016/0003-9861(74)90276-8, PMID 4155270.
  • (EN) Bornemann S, Lowe DJ, Thorneley RN, The transient kinetics of Escherichia coli chorismate synthase: substrate consumption, product formation, phosphate dissociation, and characterization of a flavin intermediate in Biochemistry, vol. 35, nº 30, 1996, pp. 9907–16, DOI:10.1021/bi952958q, PMID 8703965.
  • (EN) Bornemann S, Theoclitou ME, Brune M, Webb MR, Thorneley RN, Abell C, A Secondary beta Deuterium Kinetic Isotope Effect in the Chorismate Synthase Reaction in Bio-Organic. Chemistry., vol. 28, nº 4, 2000, pp. 191–204, DOI:10.1006/bioo.2000.1174, PMID 11034781.
  • (EN) Osborne A, Thorneley RN, Abell C, Bornemann S, Studies with substrate and cofactor analogues provide evidence for a radical mechanism in the chorismate synthase reaction in J. Biol. Chem., vol. 275, nº 46, 2000, pp. 35825–30, DOI:10.1074/jbc.M005796200, PMID 10956653.