Tirosin-chinasi B-linfoide
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| Tirosin-chinasi B-linfoide | |
|---|---|
| Gene | |
| HUGO | BLK MGC10442; MODY11 |
| Entrez | 640 |
| Locus | Chr. 8 p23.1 |
| Proteina | |
| OMIM | 191305 |
| UniProt | P51451 |
| Enzima | |
| EC number | 2.7.10.2 |
La tirosin-chinasi B-linfoide, nota anche come chinasi B-linfocitica è un enzima della famiglia delle chinasi, codificato nell'essere umano dal gene BLK[1][2].
Indice |
Interazioni [modifica]
La tirosin-chinasi B-linfoide è stata osservata interagire con l'enzima UBE3A[3].
Note [modifica]
- ^ Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (marzo 1995). Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). Oncogene 10 (3): 477–86. PMID 7845672.
- ^ Entrez Gene: BLK B lymphoid tyrosine kinase
- ^ Oda H, Kumar S, Howley PM (agosto 1999). Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. DOI:10.1073/pnas.96.17.9557. PMID 10449731.
Approfondimenti [modifica]
- Dymecki SM, Niederhuber JE, Desiderio SV (1990). Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.. Science 247 (4940): 332–6. DOI:10.1126/science.2404338. PMID 2404338.
- Lin YH, Shin EJ, Campbell MJ, Niederhuber JE (1995). Transcription of the blk gene in human B lymphocytes is controlled by two promoters.. J. Biol. Chem. 270 (43): 25968–75. DOI:10.1074/jbc.270.43.25968. PMID 7592787.
- Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). Reconstitution of the B cell antigen receptor signaling components in COS cells.. J. Biol. Chem. 270 (45): 27072–8. DOI:10.1074/jbc.270.45.27072. PMID 7592958.
- Islam KB, Rabbani H, Larsson C, et al. (1995). Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.. J. Immunol. 154 (3): 1265–72. PMID 7822795.
- Donovan JA, Wange RL, Langdon WY, Samelson LE (1994). The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.. J. Biol. Chem. 269 (37): 22921–4. PMID 8083187.
- Pleiman CM, Clark MR, Gauen LK, et al. (1993). Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.. Mol. Cell. Biol. 13 (9): 5877–87. PMID 8395016.
- Malek SN, Yang CH, Earnshaw WC, et al. (1996). p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains.. J. Biol. Chem. 271 (12): 6952–62. DOI:10.1074/jbc.271.12.6952. PMID 8636124.
- Bewarder N, Weinrich V, Budde P, et al. (1996). In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.. Mol. Cell. Biol. 16 (9): 4735–43. PMID 8756631.
- Saouaf SJ, Wolven A, Resh MD, Bolen JB (1997). Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate.. Biochem. Biophys. Res. Commun. 234 (2): 325–9. DOI:10.1006/bbrc.1997.6638. PMID 9177269.
- Hegde R, Srinivasula SM, Ahmad M, et al. (1998). Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.. J. Biol. Chem. 273 (14): 7783–6. DOI:10.1074/jbc.273.14.7783. PMID 9525867.
- Oda H, Kumar S, Howley PM (1999). Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.. Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. DOI:10.1073/pnas.96.17.9557. PMID 10449731.
- Appel S, Filter M, Reis A, et al. (2002). Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759.. Eur. J. Hum. Genet. 10 (1): 17–25. DOI:10.1038/sj.ejhg.5200750. PMID 11896452.
- Lee S, Ha S, Chung M, et al. (2003). Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells.. Cancer Lett. 188 (1-2): 121–6. DOI:10.1016/S0304-3835(02)00055-1. PMID 12406557.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932.
- Cho JY, Akbarali Y, Zerbini LF, et al. (2004). Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.. J. Biol. Chem. 279 (19): 19512–22. DOI:10.1074/jbc.M309074200. PMID 14970218.
