SOX6
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Il fattore trascrizionale SOX-6 è una proteina codificata negli esseri umani dal gene SOX6.[1][2]
| SOX-6 | |
|---|---|
 SOX6 dall'archivio PDB |
|
| Gene | |
| HUGO | SOX6 HSSOX6 |
| Entrez | 55553 |
| Locus | Chr. 11 [1] |
| Proteina | |
| OMIM | 607257 |
| UniProt | P04637 |
La famiglia dei geni SOX codifica per un gruppo di fattori trascrizionali caratterizzati dal dominio HMG (high mobility group), un dominio di legame al DNA. I fattori trascrizionali SOX, a differenza della maggior parte dei fattori trascrizionali, si legano al solco minore del DNA piegando la doppia catena di un angolo di 70-85 gradi e introducendo cambiamenti conformazionali locali.[2]
Interazioni [modifica]
È stato dimostrato che SOX6 interagisce con CTBP2[3] e CENPK.[4]
Note [modifica]
- ^ Cohen-Barak O, Hagiwara N, Arlt MF, Horton JP, Brilliant MH (marzo 2001). Cloning, characterization and chromosome mapping of the human SOX6 gene. Gene 265 (1-2): 157-64. PMID 11255018.
- ^ a b Entrez Gene: SOX6 SRY (sex determining region Y)-box 6
- ^ Murakami, A, Ishida S, Thurlow J, Revest J M, Dickson C (Aug. 2001). SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter. Nucleic Acids Res. 29 (16): 3347-55.
- ^ Yamashita, A, Ito M, Takamatsu N, Shiba T (Sep. 2000). Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis. FEBS Lett. 481 (2): 147-51.
Bibliografia [modifica]
- Denny P, Swift S, Brand N, et al. (1992). A conserved family of genes related to the testis determining gene, SRY.. Nucleic Acids Res. 20 (11): 2887. DOI:10.1093/nar/20.11.2887. PMID 1614875.
- Lefebvre V, Li P, de Crombrugghe B (1998). A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene.. Embo J. 17 (19): 5718–33. DOI:10.1093/emboj/17.19.5718. PMID 9755172.
- Hagiwara N, Klewer SE, Samson RA, et al. (2000). Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death.. Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4180–5. DOI:10.1073/pnas.97.8.4180. PMID 10760285.
- Yamashita A, Ito M, Takamatsu N, Shiba T (2000). Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis.. FEBS Lett. 481 (2): 147–51. DOI:10.1016/S0014-5793(00)01987-6. PMID 10996314.
- Hartley JL, Temple GF, Brasch MA (2001). DNA cloning using in vitro site-specific recombination.. Genome Res. 10 (11): 1788–95. DOI:10.1101/gr.143000. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.. Genome Res. 11 (3): 422–35. DOI:10.1101/gr.154701. PMID 11230166.
- Murakami A, Ishida S, Thurlow J, et al. (2001). SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter.. Nucleic Acids Res. 29 (16): 3347–55. DOI:10.1093/nar/29.16.3347. PMID 11504872.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932.
- Cohen-Barak O, Yi Z, Hagiwara N, et al. (2004). Sox6 regulation of cardiac myocyte development.. Nucleic Acids Res. 31 (20): 5941–8. DOI:10.1093/nar/gkg807. PMID 14530442.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Wiemann S, Arlt D, Huber W, et al. (2004). From ORFeome to biology: a functional genomics pipeline.. Genome Res. 14 (10B): 2136–44. DOI:10.1101/gr.2576704. PMID 15489336.
- Ueda R, Yoshida K, Kawakami Y, et al. (2005). Expression of a transcriptional factor, SOX6, in human gliomas.. Brain tumor pathology 21 (1): 35–8. DOI:10.1007/BF02482175. PMID 15696967.
- Ueda R, Yoshida K, Kawakami Y, et al. (2005). Immunohistochemical analysis of SOX6 expression in human brain tumors.. Brain tumor pathology 21 (3): 117–20. DOI:10.1007/BF02482186. PMID 15696972.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). The LIFEdb database in 2006.. Nucleic Acids Res. 34 (Database issue): D415–8. DOI:10.1093/nar/gkj139. PMID 16381901.
- Fernández-Lloris R, Osses N, Jaffray E, et al. (2006). Repression of SOX6 transcriptional activity by SUMO modification.. FEBS Lett. 580 (5): 1215–21. DOI:10.1016/j.febslet.2006.01.031. PMID 16442531.
- Ikeda T, Saito T, Ushita M, et al. (2007). Identification and characterization of the human SOX6 promoter.. Biochem. Biophys. Res. Commun. 357 (2): 383–90. DOI:10.1016/j.bbrc.2007.03.133. PMID 17433257.
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