Cellula di Cajal-Retzius

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cellule di Cajal-Retzius
Cajal-Retzius cell drawing by Cajal 1891.gif

Le cellule di Cajal-Retzius sono neuroni particolari che si trovano principalmente nella zona marginale della corteccia cerebrale.

I primi che hanno descritto queste cellule sono stati l'istologo spagnolo Santiago Ramón y Cajal e lo scienziato svedese Gustaf Retzius.

Le cellule sintetizzano e secernono la glicoproteina relina, che è la principale responsabile delle migrazioni corrette dei neuroni corticali. Si sa che la relina si accumula nel plesso assonale delle cellule di Cajal-Retzius, in cisterne assonali sferiche chiamate "serbatoi assonali di relina".

Bibliografia[modifica | modifica sorgente]

  • Retzius G (1893) Die Cajal'schen Zellen der Grosshirnrinde beim Menschen und bei Säugetieren. Biologische Untersuchungen, Neue Folge 5:1–8.
  • Retzius G (1894) Weitere Beiträge zur Kenntniss der Cajal'schen Zellen der Grosshirnrinde des Menschen. Biologische Untersuchungen. Neue Folge 6:29–36.
  • Meyer G, Goffinet AM, Fairen A. (1999) What is a Cajal-Retzius cell? A reassessment of a classical cell type based on recent observations in the developing neocortex. Cereb Cortex. 9(8):765-75.

Referenze[modifica | modifica sorgente]

  • Takiguchi-Hayashi K, Sekiguchi M, Ashigaki S, Takamatsu M, Hasegawa H, Suzuki-Migishima R, Yokoyama M, Nakanishi S, Tanabe Y. (2004) Generation of reelin-positive marginal zone cells from the caudomedial wall of telencephalic vesicles. J Neurosci. 24(9):2286-95.
  • Bar I, Lambert de Rouvroit C, Goffinet AM. (2000) The evolution of cortical development. An hypothesis based on the role of the Reelin signaling pathway. Trends Neurosci. 23(12):633-8.
  • Saito Y, Mizuguchi M, Oka A, Takashima S (2000). "Fukutin protein is expressed in neurons of the normal developing human brain but is reduced in Fukuyama-type congenital muscular dystrophy brain". Ann. Neurol. 47 (6): 756–64.
  • Meyer G, Cabrera Socorro A, Perez Garcia CG, Martinez Millan L, Walker N, Caput D. (2004) Developmental roles of p73 in Cajal-Retzius cells and cortical patterning.J Neurosci.24(44):9878-87.
  • Borrell V., Marin O. Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling. Nature Neuroscience 9(10): 1284-1293 (2006).
  • Yamazaki H. Distinct ontogenic and regional expressions of newly identified Cajal-Retzius cell-specific genes during neocorticogenesis. Proceedings of the National Academy of Sciences (USA) 101(40): 14509-1414 (2004).
  • Ogawa M. The reeler gene-associated antigen on Cajal–Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron 14: 899-912 (1995).
  • Hevner RF. Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial origin. Brain Research Developmental Brain Research 141(1-2): 39-53 (2003).
  • Mienville JM. Cajal-Retzius cell physiology: just in time to bridge the 20th century. Cerebral Cortex 9(8): 776-782 (1999).
  • D'Arcangelo G. Reelin is a secreted glycoprotein recognized by the Cajal– Retzius-50 monoclonal antibody. Journal of Neuroscience 17: 23-31 (1997).
  • Soriano E. Cajal-Retzius cells regulate the radial glia phenotype in the adult and developing cerebellum and alter granule cell migration. Neuron 18(4): 563-577 (1997).
  • Soriano E and Del Rio JA. The cells of Cajal-Retzius: still a mystery one century after. Neuron 46(3): 389-394 (2005).
  • Super H. Disruption of neuronal migration and radial glia in the developing cerebral cortex following ablation of Cajal-Retzius cells. Cereb Cortex 10(6): 602-613 (2000).
  • Del Rio JA. A role for Cajal-Retzius cells and reelin in the development of hippocampal connections. Nature 385(6611): 70-74 (1997).

Collegamenti esterni[modifica | modifica sorgente]