CLEC5A
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| CLEC5A | |
|---|---|
| Gene | |
| HUGO | CLEC5A CLECSF5; MDL-1; MDL1 |
| Entrez | 23601 |
| Locus | Chr. 7 q34 |
| Proteina | |
| OMIM | 604987 |
| UniProt | Q9NY25 |
CLEC5A (dall'acronimo in lingua inglese C-type LECtin domain family 5 member A) è una lectina che sembra avere un ruolo significativo nella attivazione della linea mieloide dell'emopoiesi[1][2].
Note[modifica]
- ^ Entrez Gene: C-type lectin domain family 5
- ^ Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL (August 1999). Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc. Natl. Acad. Sci. U.S.A. 96: 9792–6. DOI:10.1073/pnas.96.17.9792.
Approfondimenti[modifica]
- Chen ST, Lin YL, Huang MT, et al. (2008). CLEC5A is critical for dengue-virus-induced lethal disease.. Nature 453: 672–6. DOI:10.1038/nature07013.
- Davila S, Froeling FE, Tan A, et al. (2010). New genetic associations detected in a host response study to hepatitis B vaccine.. Genes Immun. 11: 232–8. DOI:10.1038/gene.2010.1.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). Human chromosome 7: DNA sequence and biology.. Science 300: 767–72. DOI:10.1126/science.1083423.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). The DNA sequence of human chromosome 7.. Nature 424: 157–64. DOI:10.1038/nature01782.
- Ebner S, Sharon N, Ben-Tal N (2003). Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.. Proteins 53: 44–55. DOI:10.1002/prot.10440.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121–7. DOI:10.1101/gr.2596504.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99: 16899–903. DOI:10.1073/pnas.242603899.
- Drickamer K (1999). C-type lectin-like domains.. Curr. Opin. Struct. Biol. 9: 585–90. DOI:10.1016/S0959-440X(99)00009-3.
- Watson AA, O'Callaghan CA (2010). Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor.. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66: 29–31. DOI:10.1107/S1744309109047915.
